Summary
Exceptionally Large and
Innovative Pipeline
The prostate cancer
pipeline is among the largest in the pharmaceutical industry with 484 products
in active development across all stages. The range of mechanisms of action
employed by these compounds is also highly diverse, especially in comparison to
the existing market landscape. More pertinently, the degree and proportion of
breakthrough innovations in this pipeline is exceptional; GBI Research analysis
identified 174 first-in-class programs in the prostate cancer pipeline, acting
on 122 first-in-class molecular targets. This accounts for some 36% of all
products with a disclosed molecular target and is reflective of the high degree
of innovation in this indication. This has far-reaching strategic implications
for all market participants, as, despite the high attrition rate in prostate
cancer, it is highly likely many of the first-in-class technologies will reach
the market over the coming decade and may transform the clinical and commercial
landscape.
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Alignment of
First-in-Class Molecular Target with Disease Causation
One of the key trends in
oncology and in prostate cancer in particular over the last decade is the
clinical and commercial impact of targeted therapies designed to target
proteins in signaling pathways that are strongly associated with disease
progression. By aligning the molecular targets for therapeutic intervention
with disease causation and/or propagation, these therapies limit the systemic
cytotoxic effects whilst inhibiting tumor-promoting signaling pathways. Such
strategies thereby typically achieve superior efficacy and safety
profiles.
Our proprietary analyses
demonstrate significant levels of differentiation as to how well the
first-in-class products and their respective molecular targets align to
underlying gene and protein level mutations and dysfunction. More advanced
analytics further substantiated these findings as strong levels of
differentiation in the scientific and clinical rationale for first-in-class
molecular targets emerged. Furthermore, clear frontrunners were identified by
integrating analyses to assess the accessibility of molecular targets for
therapeutic compounds, the size of the target patient population that would
benefit from therapeutic intervention, and the expected positioning of the
first-in-class products based on the molecular targets and mechanisms of action
of currently marketed products.
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